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Using amphetamines (uppers) on a long trip is dangerous because they:

  1. Create a false sense of alertness

  2. Cause drowsiness at first

  3. Produce immediate physical and mental letdown

  4. Decrease reaction time

The correct answer is: Create a false sense of alertness

Amphetamines are stimulants that can create a false sense of alertness. This is dangerous because it can mask feelings of fatigue and inhibit the body's natural warning signals, making it difficult to recognize when rest is needed. Option B is incorrect because amphetamines do not typically cause drowsiness at first. Option C is incorrect because while amphetamines can lead to a mental and physical "crash" once the effects wear off, this would not happen immediately. Option D is incorrect because amphetamines actually increase reaction time.